Chemical & Petroleum Engineering

Michael KallosMichael Kallos

Associate Professor

Associate Director Pharmaceutical Production Research Facility (PPRF)
1995 - 1999: Ph.D. Chemical Engineering, University of Calgary
1991 - 1995: B.Sc. Chemical Engineering with Distinction, University of Calgary

Awards / Accolades

Although born in Cape Town, South Africa, Dr. Kallos is a native to Calgary. He graduated with his PhD in 1999 from the University of Calgary and he is currently working in the area of biochemical and biomedical engineering.

He was recently appointed as Associate Director of the Pharmaceutical Production Research Facility (PPRF), where he collaborates with Dr. Leo Behie and Dr. Arin Sen. Dr. Kallos is working on a project at PPRF to grow human neural stem cells used to treat Parkinson's. Kallos is also working on projects to generate clinically relevant quantities of pancreatic progenitors, hepatic oval stem cells and muscle-derived stem cells. He has also been heavily involved in the graduate and undergraduate Biomedical Engineering program at the University of Calgary.

Research interests:

Tissue engineering, bioreactor design, cell culture, biotechnology, animal cells, neural stem cells, hepatic oval stem cells, serum-free medium development, chemical reactor kinetics.

Recent Papers:

2007

  1. zur Nieden, NI, Cormier, JT, Rancourt, DE, Kallos, MS, "Embryonic Stem Cells Remain Highly Pluripotent Following Long Term Expansion as Aggregates in Suspension Bioreactors", Journal of Biotechnology 129, 421-432 (2007), (Published Online 21 January 2007: doi: 10.1016/j.jbiotec.2007.01.006)

  2. Meng GL, zur Nieden NI, Liu SY, Cormier JT, Kallos MS, Rancourt DE, "Properties of murine embryonic stem cells maintained on human foreskin fibroblasts without LIF" (Accepted May 3, 2007 in Molecular Reproduction and Development, Manuscript Number MRD-07-0059)

2006

  1. Bodnar, C., Sen A., Kallos, M.S., Behie, L.A., Petropavlovskaia, M., and Rosenberg, L., "Characterization of Human Islet-Like Structures Generated from Pancreatic Progenitor Cells in Culture", Biotechnology and Bioengineering 93(5), 980-988 (2006). (Published Online December 12, 2005: DOI 10.1002/bit.20801).

  2. Chawla, M., Bodnar, C.A., Sen A., Kallos, M.S., and Behie, L.A. "Production of Islet-Like Structures from Neonatal Porcine Pancreatic Tissue in Suspension Bioreactors", Biotechnology Progress 22(2), 561-567 (2006) (Published Online: 11 Mar 2006: DOI: 10.1021/bp050261i).

  3. Gilbertson, J., Sen, A., Behie, L.A., and Kallos, M.S., "Scaled-up Production of Mammalian Neural Stem and Progenitor Cells in Computer-Controlled Suspension Bioreactors" Biotechnology and Bioengineering 94(4) 783-792 (2006). (Published Online: 17 Feb 2006: DOI: 10.1002/bit.20900).

  4. Wang, T.Y., Sen, A., Behie, L.A., and Kallos, M.S., "Dynamic Behaviour of Cells within Neurospheres in Expanding Populations of Neural Precursors" Brain Research 1107, 82-96 (2006). (Published Online 21 July 2006: DOI: 10.1016/j.brainres.2006.05.110)

  5. Cormier, JT, zur Nieden, NI, Rancourt, DE, Kallos, MS, "Expansion of Undifferentiated Murine Embryonic Stem Cells as Aggregates in Suspension Culture Bioreactors" Tissue Eng 12(11) 3233-3245 (2006).

2005

  1. Youn, B.S., Sen, A., Kallos, M.S., Girgis-Gabardo, A., Barcelon, M., Kurpios, N., Hassell, J.A., Behie L.A., "Large-Scale Expansion of Murine Mammary Epithelial Stem Cells in Suspension Bioreactors", Biotechnology Progress 21(3), 984-993 (2005).

2004

  1. Behie, L.A., A. Sen and M.S. Kallos, "Bioprocessing Aspects of Neural Stem Cell Production in Bioreactors", BioProcessing Journal, Feature Article, 3(4), 27-42 (2004).

  2. Sen, A., M.S. Kallos and L.A. Behie, "A New Tissue Dissociation Protocol for Scaled-Up Production of Neural Stem Cells in Suspension Bioreactors", Tissue Engineering, 10(5-6), 904-913 (2004).

  3. Alam, S., Sen, A., Behie, L.A., and Kallos, M.S., "Cell cycle kinetics of expanding populations of neural stem cells in vitro", Biotechnology and Bioengineering, 88(3), 332-347 (2004).

2003

  1. Kallos, M.S., Sen, A., and Behie, L.A., "Large-Scale Expansion of Mammalian Neural Stem Cells: A Review", Medical & Biological Engineering and Computing, 41(3), 271-282 (2003).

2002

  1. Sen, A., Kallos, M.S., and Behie, L.A., "Expansion of Mammalian Neural Stem Cells in Bioreactors: Effect of Power Input and Medium Viscosity", Developmental Brain Research, 134(1-2) 103-113 (2002).

  2. Sen, A., Kallos, M.S., and Behie, L.A., "Passaging Protocols for Mammalian Neural Stem Cells in Suspension Bioreactors", Biotechnology Progress, 18(2) 337-345 (2002).

2001

  1. Sen, A., Kallos, M.S., and Behie, L.A., "Hydrodynamic Effects on Extended Cultures of Mammalian Neural Stem Cell Aggregates in Suspension Culture", Industrial Engineering Chemistry, 40(23) 5350-5357 (2001), and an invited Plenary Lecture presented at "Chemical Reaction Engineering VIII", Barga, Italy (June 24-29, 2001).

1999

  1. Kallos, M.S. and L.A. Behie, "Inoculation and Growth Conditions for High Cell Density Expansion of Mammalian Neural Stem Cells in Suspension Bioreactors", Biotechnology and Bioengineering 63(4), 473-483 (1999).

  2. Kallos, M.S., A.L. Vescovi, and L.A. Behie, "Extended Serial Passaging of Mammalian Neural Stem Cells in Suspension Bioreactors", Biotechnology and Bioengineering 65(5), 589-599 (1999).

1998

  1. Kallos, M.S., B.A, Reynolds, A.L. Vescovi and L.A. Behie, "High Cell Density Growth of Mammalian Neural Stem Cells as Aggregates in Bioreactors", in the book Fluidization IX, Eds. L.S. Fan and T.M. Knowlton, Publ. Engineering Foundation, New York, 653-660 (1998).